Design and Simulation of a DNA Tile Self-Assembly-Based Molecular Processor for microRNA Detection
Subject Areas : electrical and computer engineering
1 - Comp. Eng. Faculty, Isfahan University, Isfahan, Ira
Keywords: Molecular processors, early disease detection, DNA self-assembly, DNA-based computing.,
Abstract :
Nowdays, the design of molecular processors for disease diagnosis, particularly early cancer detection, has become one of the most active research and technology areas. In this paper, DNA-based molecular processors are introduced. First, controllable and scalable self-assembly tiles were designed. These tiles, implemented using hairpin DNA strands, are capable of receiving single-stranded inputs, generating outputs that can be utilized in subsequent steps, and enabling cascading connections across different levels. In the next step, basic logic gates (AND, OR, NOT) were constructed using the designed tiles, and a processor for detecting 12 microRNAs, aimed at early cancer diagnosis, was implemented. Simulations were performed using the VisualDSD tool under a deterministic model. The simulation results for the considered test set achieved PPV ≈ 0.91 and NPV ≈ 0.99, demonstrating the promising performance of the designed processor.
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