طراحی و شبیهسازی پردازندهی مولکولی با کاشیهای خودسامانی مبتنی بر دیانای جهت تشخیص ریزرِناها
زهره بیکی
1
(
دانشكده مهندسی كامپيوتر، دانشگاه اصفهان، اصفهان، ایران
)
کلید واژه: پردازندههای مولکولی, تشخیص زودهنگام بیماری, خودسامانی رشتههای دِنا, محاسبات مبتنی بر دِنا,
چکیده مقاله :
امروزه طراحی پردازشگرهای مولکولی جهت تشخیص بیماریها از جمله تشخیص زودهنگام سرطان به یکی از حوزهی داغ تحقیقاتی و فناوری تبدیل شده است. در این مقاله پردازندههای مولکولی مبتنی بر دنا معرفی شده است. ابتدا کاشیهای خودسامانی کنترل پذیر و قابل گسترش طراحی شده. در این کاشیها که با استفاده از رشتههای سنجاقسر پیادهسازی شده است امکان دریافت تک رشتههای ورودی و تولید خروجی قابل استفاده در مراحل بعد و اتصال آبشاری بین سطوح مختلف فراهم شده است. در گام بعدی با استفاده از کاشیهای طراحی شده دروازههای منطقی پایه (AND ,OR ,NOT) طراحی شده و پردازشگری جهت تشخیص ۱۲ ریزرِنای با هدف تشخیص زودهنگام سرطان پیادهسازی شد؛ شبیهسازیها با ابزار VisualDSD و با مدل قطعی انجام شدهاند. نتایج شبیهسازی برای مجموعهی آزمایشی مدنظر دارای 91/0 ≈PPV و 99/0≈NPV است که نشان از عملکرد مناسب پردازشگر طراحی شده دارد.
چکیده انگلیسی :
Nowdays, the design of molecular processors for disease diagnosis, particularly early cancer detection, has become one of the most active research and technology areas. In this paper, DNA-based molecular processors are introduced. First, controllable and scalable self-assembly tiles were designed. These tiles, implemented using hairpin DNA strands, are capable of receiving single-stranded inputs, generating outputs that can be utilized in subsequent steps, and enabling cascading connections across different levels. In the next step, basic logic gates (AND, OR, NOT) were constructed using the designed tiles, and a processor for detecting 12 microRNAs, aimed at early cancer diagnosis, was implemented. Simulations were performed using the VisualDSD tool under a deterministic model. The simulation results for the considered test set achieved PPV ≈ 0.91 and NPV ≈ 0.99, demonstrating the promising performance of the designed processor.
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